Polymeric micelle as therapeutic siRNA carrier for axonal regeneration in spinal cord injury
نویسندگان
چکیده
منابع مشابه
Spontaneous axonal regeneration in rodent spinal cord after ischemic injury.
Here we present evidence for spontaneous and long-lasting regeneration of CNS axons after spinal cord lesions in adult rats. The length of 200 kD neurofilament (NF)-immunolabeled axons was estimated after photochemically induced ischemic spinal cord lesions using a stereological tool. The total length of all NF-immunolabeled axons within the lesion cavities was increased 6- to 10-fold at 5, 10,...
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Traumatic spinal cord injury (SCI) results in a cascade of tissue responses leading to cell death, axonal degeneration, and glial scar formation, exacerbating the already hostile environment and further inhibiting axon regeneration. Overcoming these inhibitory cues and promoting axonal regeneration is one of the primary targets in developing a cure for SCI. Previously, we demonstrated that tran...
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THERAPEUTIC STRATEGIES AIMED TO FACILITATE AXONAL REGENERATION AND FUNCTIONAL RECOVERY FOLLOWING TRAUMATIC SPINAL CORD INJURY By Woon Chow, B.S., B.S. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctorate of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2011 Major Director: Raymond Colello, D.Phil. Associate Professor...
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Spinal cords of sea lamprey larvae were transected at one of two levels: (a) rostral, at the last gill, or (b) caudal, at the cloaca. Following various recovery times, regeneration of the posteriorly projecting giant reticulospinal axons (RAs) was demonstrated by intra-axonal injection of horseradish peroxidase (HRP). Regeneration of axons of anteriorly projecting dorsal cells (DCs) and giant i...
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ژورنال
عنوان ژورنال: Frontiers in Bioengineering and Biotechnology
سال: 2016
ISSN: 2296-4185
DOI: 10.3389/conf.fbioe.2016.01.02986